Profesor Madya Dr. Abdel Mohsen Mohamed Ahmed Abdel Hafez

Fakulti Perubatan Dan Sains Kesihatan, UMS

Pemphigoid Gestationis A Letriture review Mohsen M A Abdelhafez Karim A M Ahmed Fairdaus Hayatti Fairrul Kadir Mohamed saffre Mohd Nazri Dg Marshitta Ehab Helmy Win win Than ABSTRACT Pemphigoid Gestationis(PG),also known as gestational pemphigoid as it is specifically associated with a pregnancy event,is one of the rare pregnancy-related dermatomes,characterised by the formation of auto antibodies against Bullous Pemphigoid antigen180(BP180) causing significant damage to the basement membrane of the skin resulting in marked pruritus and blisters on the abdomen and extremities .Diagnosis of PG is basically made by the characteristic clinical picture and confirmed by immunofluorescence studies of a skin biopsy.Treatment,like other autoimmune dermatomes,is achieved by corticosteroids with the risk of relapses in subsequent pregnancies.Fetal growth restriction and prematurity are potential fetal complications associated with the disease,hence the recommended combined antenatal care by a dermatologist as well as an obstetrician,however,the disease is unlikely to be a source of significant maternal morbidity or mortality.